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Numerical complete solution for random genetic drift by energetic variational approach
Journal article

Numerical complete solution for random genetic drift by energetic variational approach

Chenghua Duan, Chun Liu, Cheng Wang and Xingye Yue
Mathematical Modeling and Numerical Analysis, Vol.53(2), pp.615-634
2019

Abstract

Random genetic drift wright-fisher model energetic variational approach convex splitting scheme Dirac delta singularity fixation phenomenon
"In this paper, we focus on numerical solutions for random genetic drift problem, which is governed by a degenerated convection-dominated parabolic equation. Due to the fixation phenomenon of genes, Dirac delta singularities will develop at boundary points as time evolves. Based on an energetic variational approach (EnVarA), a balance between the maximal dissipation principle (MDP) and least action principle (LAP), we obtain the trajectory equation. In turn, a numerical scheme is proposed using a convex splitting technique, with the unique solvability (on a convex set) and the energy decay property (in time) justified at a theoretical level. Numerical examples are presented for cases of pure drift and drift with semi-selection. The remarkable advantage of this method is its ability to catch the Dirac delta singularity close to machine precision over any equidistant grid."

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