Abstract
CBC - Complete blood count, RDT - Rapid Diagnostic Test, RBCs - Red blood cells, CDC - Centers for Disease Control and Prevention, AST - Aspartate Aminotransferase, ALT - Alanine Aminotransferase INDEX TERMS: [...]all of the false negative RDTs most likely were due to infection with P. ovale. The BinaxNOW Malaria test (BN) is the first and only Food and Drug Administration (FDA) approved rapid test for malaria in the United States.13 This qualitative test utilizes monoclonal antibodies to identify histidine-rich proteins that are specific for P. falciparum, and aldolase, which is a major enzyme in the glycolytic pathway of malarial parasites, in an EDTA whole blood specimen.1,6 Commercial antibodies are separated out along a membrane; if malarial antigens are present when the specimen is added, they will bind to trapped antibodies on the membrane and form a visible test line under the control line after addition of reagent. For P. malariae, the diagnostic sensitivity was only 43.8% for 16 microscopically positive malaria samples and 50% diagnostic sensitivity for two P. ovale samples. [...]the diagnostic sensitivity of the BinaxNow test kit was low for P. ovale, however, an insufficient number of positive samples for these parasites were tested in the study.