Long-Duration Type 1 Diabetes Alters Bone Matrix Composition but Does Not Influence Microarchitecture or Mechanical Behavior in Femoral Trabecular Bone in Older Adults

Shannon R Emerzian; Jackson Hanlon; Ramina Behzad; Mustafa Unal; Daniel J Brooks; I-Hsien Wu; Surya Vishva Teja Jangolla; Marc Gregory Yu; Hetal S Shah; George L King; Fjola Johannesdottir; Lamya Karim; Elaine W Yu; Mary L. Bouxsein

Long-Duration Type 1 Diabetes Alters Bone Matrix Composition but Does Not Influence Microarchitecture or Mechanical Behavior in Femoral Trabecular Bone in Older Adults

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Peer reviewed

Long-Duration Type 1 Diabetes Alters Bone Matrix Composition but Does Not Influence Microarchitecture or Mechanical Behavior in Femoral Trabecular Bone in Older Adults

Shannon R Emerzian, Jackson Hanlon, Ramina Behzad, Mustafa Unal, Daniel J Brooks, I-Hsien Wu, Surya Vishva Teja Jangolla, Marc Gregory Yu, Hetal S Shah, George L King, …

Proceedings of the 46th Annual Meeting for the American Society for Bone and Mineral Research

Annual Meeting for the American Society for Bone and Mineral Research, 46

09/29/2024

Abstract

Bioengineering

Increased hip fracture risk in type 1 diabetes (T1D) is not solely due to lower bone mineral density (BMD), indicating potential alterations in bone material contributing to mechanical deficiencies. T1D may affect bone mechanical properties through advanced glycation end product (AGE) accumulation and altered matrix composition. However, there is limited data on human trabecular bone in T1D. This study assesses trabecular bone tissue material behavior, AGE content, and composition in cadaveric femora from older adults with T1D and nondiabetic controls.

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Title: Long-Duration Type 1 Diabetes Alters Bone Matrix Composition but Does Not Influence Microarchitecture or Mechanical Behavior in Femoral Trabecular Bone in Older Adults
Creators: Shannon R Emerzian - Beth Israel Deaconess Medical Center
Jackson Hanlon - Beth Israel Deaconess Medical Center
Ramina Behzad - University of Massachusetts Dartmouth
Mustafa Unal - Beth Israel Deaconess Medical Center
Daniel J Brooks - Beth Israel Deaconess Medical Center
I-Hsien Wu - Joslin Diabetes Center
Surya Vishva Teja Jangolla - Joslin Diabetes Center
Marc Gregory Yu - Joslin Diabetes Center
Hetal S Shah - Joslin Diabetes Center
George L King - Joslin Diabetes Center
Fjola Johannesdottir - Beth Israel Deaconess Medical Center
Lamya Karim - University of Massachusetts Dartmouth, Department of Bioengineering
Elaine W Yu - Massachusetts General Hospital
Mary L. Bouxsein - Beth Israel Deaconess Medical Center
Publication Details: Proceedings of the 46th Annual Meeting for the American Society for Bone and Mineral Research
Conference: Annual Meeting for the American Society for Bone and Mineral Research, 46
Academic Unit: Department of Bioengineering
Language: English
Resource Type: Conference proceeding
Record Identifier: 9914474405101301

Long-Duration Type 1 Diabetes Alters Bone Matrix Composition but Does Not Influence Microarchitecture or Mechanical Behavior in Femoral Trabecular Bone in Older Adults

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